Category: Africa

African Coronavirus News

SARS-CoV-2 in Angola from 23rd September 2019

“Our findings demonstrate that SARS-CoV-2-reactive antibodies were detected in 40 out of 442 specimens, as early as September 23, 2019”

This retrospective study on blood specimens from measles patients collected from 23 September 2019 to 28 February 2020, reported from the 17 provinces of Angola, suggests evidence of SARS-CoV-2 infection months before detection of the virus in Luanda, the epicenter of SARS-CoV-2 infection in Angola.  More...

Coronaheadsup.com Africa, Angola, Coronavirus, Evolution, Genome, Infection, Origins, PCR, Testing, Transmission, Vaccine

Preprint: SARS-CoV-2 infects and replicates in human testes

“The virus remains infective after a long infection period in the testes (viral reservoir)”

This is the first study that shows:
1) the high SARS-CoV-2 tropism to the testis
2) one mode of SARS-CoV-2 entrance in testes
3) SARS-CoV-2 preferred infection and replication in spermatogonia and macrophages
4) that the virus remains infective after a long infection period in the testes (viral reservoir)
5) high levels of angiotensin II and activated mast cells and macrophages are critical players in promoting all testicular alterations
6) the more extended severe condition, the lower the number of surviving germ cells
7) fluctuation in several essential testicular genes
8) that the intratesticular testosterone levels are 30 times reduced in testes of COVID-19 patients
9) the prevalent types of collagen present in SARS-CoV-2 mediated testicular fibrosis
10) the fluctuation of vasoconstrictive peptides in testes of COVID-19 critically ill patients

Medrxiv Preprint: SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes

 

Sars-CoV-2 – checkmate to the virus in four moves

 

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