Long COVID patients lack naive T and B cells

Nature article: “Patients with long COVID had highly activated innate immune cells, lacked naive T and B cells and showed elevated expression of type I IFN (IFN-β) and type III IFN (IFN-λ1) that remained persistently high at 8 months after infection”

“T cell activation (indicated by CD38 and HLA-DR), T cell exhaustion and increases in B cell plasmablasts occur during severe COVID-19”

Full Nature article: Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

 

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Long COVID in 2009: Mental Morbidities and Chronic Fatigue in SARS Survivors

From 2009, Long COVID in SARS survivors:   Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, and 27.1% met the modified 1994 Centers for Disease Control and Prevention criteria for chronic fatigue syndrome.   More...