Category: N501Y
Sars-Cov-2 lab variant bound 600 times more successfully to human cells than the original strain
The naturally selected mutations S477N, E484K, and N501Y of the Spike protein RBD, which show higher infectivity, were selected by yeast surface display affinity maturation already in the first round, giving rise to the South-African, E484K, N501Y, and British variants that bind ACE2 13 and 3.5-fold tighter than RBD-WT. More...
Novavax vaccine works well except on N501Y.V2 South Africa variant
An early analysis in Britain found that the Novavax vaccine had an efficacy rate of nearly 90 percent. More...
SARS-CoV-2 501YV2 escapes neutralization by South African COVID-19 donor plasma
SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
“SARS-CoV-2 501Y.V2, More...
Major outbreak of SARS-CoV-2 South African Variant 501YV2 in Ostend, Belgium
Belgium has declared its first major outbreak of the South African variant of the virus that causes Covid-19 [501Y.V2], More...
Study of convalescent sera from 44 South Africans infected in first wave, >90% showed reduced immunity & 48% had complete immune escape to 501Y.V2
Study of convalescent sera from 44 South Africans infected in first wave >90% showed reduced immunity and 48% had complete immune esape to 501Y.V2 More...
Scientists discuss the new South African SARS-CoV-2 variant 501Y.V2
Scientists have new biological evidence that a South African variant of Covid-19 binds more readily to human cells, making it more infectious, according to one of the world’s leading infectious disease experts. More...
Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2
“As of 7th Jan 2021, 45 countries had reported the presence of B.1.1.7 and 13 countries had reported B.1.351/501Y.V2. More...
Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus, Brazil
“We have detected a new variant circulating in December in Manaus, Amazonas state, north Brazil, where very high attack rates have been estimated previously. More...
Emergence and rapid spread of a new SARS-CoV-2 lineage with multiple spike mutations in South Africa
“Here, we describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y) that may have functional significance. More...
UK coronavirus variant B.1.1.7, N501Y found in Amsterdam, Netherlands
Two cases of British coronavirus mutation found in Amsterdam
A highly contagious mutation of the SARS-CoV-2 coronavirus which was linked to two weeks of rising infections in the United Kingdom has also been found in two people in the region of Amsterdam. More...