Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 coronavirus infection in vitro

Both itraconazole–remdesivir and fluoxetine–remdesivir combinations inhibited the production of infectious SARS‐CoV‐2 particles > 90%
We tested the antiviral potential of the antifungal itraconazole and the antidepressant fluoxetine on the production of infectious SARS‐CoV‐2 particles in the polarized Calu‐3 cell culture model and evaluated the added benefit of a combinatory use of these host‐directed drugs with the direct acting antiviral remdesivir, an inhibitor of viral RNA polymerase. 
 More...

1,039 cases of Brazilian coronavirus variant P.1 reported in Canada

 More...

Evidence for increased vaccine breakthrough rates of coronavirus variants of concern in BNT162b2 Pfizer-BionTech mRNA vaccinated individuals

Here, we performed a case-control study that examined whether BNT162b2 (Pfizer-BionTech) vaccinees with documented SARS-CoV-2 infection were more likely to become infected with B.1.1.7 or B.1.351 compared with unvaccinated individuals.  More...

Washington State: 102 coronavirus vaccine breakthrough cases reported, 8 hospitalizations, 2 deaths

Out of one million fully vaccinated individuals in Washington state, epidemiologists report evidence of 102 breakthrough cases since February 1, 2021, which represents .01 percent of vaccinated people in Washington.  More...

Contact Us